The new NFL season kicks off with a classic NFC West rivalry as the San Francisco 49ers meet the Seattle Seahawks in Week 1.
The game takes place on Sunday, September 7 at Lumen Field with kickoff set for 4:05 PM ET.
Both teams enter with high hopes and fresh storylines. The 49ers look to make another strong run behind Brock Purdy and Christian McCaffrey, while the Seahawks aim to prove they can challenge for the division at home in front of their fans.
49ers vs Seahawks Game Details at a Glance
| Matchup | San Francisco 49ers vs Seattle Seahawks |
| Week | NFL Week 1 |
| Date | Sunday, September 7, 2025 |
| Time | 4:05 PM ET (1:05 PM PT) |
| Venue | Lumen Field, Seattle |
| TV Channel | FOX |
| Streaming | FOX One (7-day free trial), NFL+ (mobile and tablet) |
| Odds | 49ers –1.5, Over/Under ~43.5 |
49ers vs Seahawks Live Score, Key Statistics & Results Updates
Fans can follow the live score here once the game begins. A scoreboard box will update in real time with every touchdown, field goal, and key play.
After the final whistle, this section will show the full results, along with key statistics such as passing yards, rushing totals and turnovers. That way you can get a clear picture of how the game played out even if you miss the live action.
How to Watch 49ers vs Seahawks Live Stream Online
The 49ers vs Seahawks game will air on FOX with kickoff at 4:05 PM ET. For fans who prefer streaming, there are easy choices. FOX One, the new streaming service from FOX, will show the game live and also offers a 7-day free trial for new users.
YouTube TV is another option, carrying FOX in most regions and including NFL RedZone & NFL Sunday Ticket on select plans. Fans on the go can also follow through NFL+, which works on phones and tablets.
With these options, you can watch the game live at home or while traveling.
Can I Watch 49ers vs Seahawks for Free?
Yes, fans can watch without paying right away. FOX One offers a 7-day free trial, which includes this week’s game. Fubo also offers a free trial in many regions, letting new users stream FOX games for the first week.
These trials make it simple to enjoy the 49ers vs Seahawks without a long commitment. Just remember to cancel before the trial ends if you don’t want to keep the plan.
Injury Report & Team News
The 49ers face questions around Christian McCaffrey, who has been dealing with a calf issue. He says he feels fine but his status will be watched closely. Tight end George Kittle is expected to play and could be a key target for Brock Purdy. On defense, the 49ers look different from last season with new faces like Bryce Huff and Richie Grant joining Nick Bosa.
For the Seahawks, the backfield looks strong with Kenneth Walker and Zach Charbonnet both ready. Their defense has improved under new coordinator Mike Macdonald, with leaders like Jarran Reed focused on stopping San Francisco’s balanced attack.
These updates could shape how each team starts their season in this rivalry game.
Game Preview and Our Prediction
The 49ers will lean on Brock Purdy to run Kyle Shanahan’s offense. If Christian McCaffrey plays at full speed, he can change the game with his running and catching. Seattle will counter with a stronger defense and a run game led by Kenneth Walker and Zach Charbonnet.
Oddsmakers give the 49ers a small edge at –1.5, with the total points line near 43.5. Some experts see San Francisco pulling out a close win, while others think Seattle can surprise at home.
Our call is a tight contest that stays close into the fourth quarter. With both sides strong in the run game, the defense that forces the key turnover late will likely win. A final score around 49ers 23, Seahawks 20 feels right for this matchup.
The 49ers and Seahawks open the season with a classic rivalry game in Seattle. Both teams have talent on both sides of the ball and the matchup should stay close.
Fans can watch on FOX or stream with FOX One and Fubo. Expect a hard fight that could come down to the last drive.
