Week 6 of the 2025 NFL season brings a packed lineup with divisional clashes, overseas games and major playoff implications. Teams are beginning to separate themselves — some chasing momentum, others trying to stop the slide.
Here’s a full look at every matchup, with expert insights and predictions to guide your Week 6 picks.
NFL Week 6 Game-by-Game Predictions
Thursday Night Football – Oct 9
Philadelphia Eagles at New York Giants – 8:15 p.m. ET on Prime Video
The Eagles’ meltdown against Denver was their first major stumble of the season. Philadelphia still ranks top-five in total offense and second in rushing touchdowns.
The Giants, on the other hand, lead the league in giveaways and struggle to protect Daniel Jones. Expect Jalen Hurts and D’Andre Swift to control the clock early.
Pick: Eagles
Sunday International Game in London – Oct 12
Denver Broncos vs New York Jets – 9:30 a.m. ET on NFL Network
Denver enters London at 3–2 after rallying from a 17–3 deficit last week. Russell Wilson’s efficiency on third down (68%) has been key. The Jets haven’t topped 20 points once this season and average only 4.8 yards per play.
Denver’s pass rush, led by Patrick Surtain II and Baron Browning, should pressure Zach Wilson into mistakes.
Pick: Broncos
Sunday Early Games – Oct 12 (1:00 p.m. ET)
Los Angeles Rams at Baltimore Ravens – FOX
The Rams are 4–1 and averaging 29 points per game. Matthew Stafford ranks third in completion rate against the blitz. The Ravens’ defense has allowed 177 points — worst in the league — and struggles in coverage.
Unless Lamar Jackson turns this into a shootout, Los Angeles wins big.
Pick: Rams
Dallas Cowboys at Carolina Panthers – FOX
The Cowboys have scored 77 points in their last two games. Dak Prescott has thrown seven touchdowns over that stretch. Carolina is tough at home but ranks 28th against the run.
Tony Pollard and CeeDee Lamb should have open lanes all game.
Pick: Cowboys
Arizona Cardinals at Indianapolis Colts – FOX
Three straight losses on final-second field goals show the Cardinals can’t close. Daniel Jones has guided Indianapolis to 4–1 with better pocket control and fewer turnovers.
The Colts’ defense ranks top-10 in takeaways and should capitalize late.
Pick: Colts
Seattle Seahawks at Jacksonville Jaguars – FOX
Sam Darnold is completing 72% of his throws and ranks fifth in yards per attempt. Jacksonville’s secondary allows over 265 passing yards per game and remains inconsistent.
Seattle’s balance between Kenneth Walker’s ground game and Darnold’s play-action keeps the Jaguars off rhythm.
Pick: Seahawks
Los Angeles Chargers at Miami Dolphins – CBS
Justin Herbert has been sacked only six times in five games — the best rate in the AFC. Miami has lost two straight by double digits and ranks near the bottom in red-zone defense.
Expect a shootout, but Herbert’s poise under pressure gives the Chargers the edge.
Pick: Chargers
Cleveland Browns at Pittsburgh Steelers – CBS
Dillon Gabriel flashed potential in Week 5 but faces a rested Steelers defense that’s tied for second in sacks.
Pittsburgh is 2–0 at home this season and allows just 15 points per game at Acrisure Stadium. Mike Tomlin’s unit dominates up front.
Pick: Steelers
New England Patriots at New Orleans Saints – CBS
Drake Maye has led New England to back-to-back wins and ranks top-10 in passer rating among rookies through five weeks. The Saints’ offense remains sluggish under Spencer Rattler, scoring just 17 points per game.
Bill Belichick’s defense wins this one with field position and clock control.
Pick: Patriots
Sunday Late Games – Oct 12 (4:00 p.m. ET)
Tennessee Titans at Las Vegas Raiders – FOX
Cam Ward’s confidence grew after a dramatic comeback win, but the Titans still rank last in passing offense. The Raiders’ pass rush, led by Maxx Crosby, will be too much for Tennessee’s young line.
Expect a close finish but a Vegas bounce-back win.
Pick: Raiders
San Francisco 49ers at Tampa Bay Buccaneers – CBS
A clash of NFC heavyweights. The 49ers average 27.8 points per game behind Christian McCaffrey’s league-leading 8 touchdowns. Tampa Bay’s defense ranks fourth against the run and forces 1.7 takeaways per game.
Baker Mayfield’s late-game confidence at home makes the difference in a thriller.
Pick: Buccaneers
Cincinnati Bengals at Green Bay Packers – CBS
Jordan Love continues to grow with 11 total touchdowns through five games. The Bengals’ offense averages under 14 points with Jake Browning under center.
Green Bay’s front seven should dominate this matchup, keeping Cincinnati scoreless for long stretches.
Pick: Packers
Sunday Night Football – Oct 12
Detroit Lions at Kansas City Chiefs – 8:20 p.m. ET on NBC
The Lions are the hottest team in football with four straight wins. Jared Goff leads the NFL in third-down conversions, while Amon-Ra St. Brown is on pace for a 1,600-yard season.
Kansas City has failed to reach 25 points in three of five games. Detroit’s physical front line gives them control and an emotional statement win on national TV.
Pick: Lions
Monday Night Football Doubleheader – Oct 13
Buffalo Bills at Atlanta Falcons – ESPN, 7:00 p.m. ET
Buffalo’s offense ranks second in yards per play (6.3) but stumbled in Week 5. Josh Allen and Stefon Diggs should bounce back against Atlanta’s soft coverage.
Expect early deep strikes and a dominant response.
Pick: Bills
Chicago Bears at Washington Commanders – ABC, 8:15 p.m. ET
Caleb Williams has the Bears’ offense rolling, but Jayden Daniels has turned Washington’s attack into one of the most balanced in the NFC. The Commanders average 31 points in home games this year.
Expect another high-scoring finish decided by a field goal.
Pick: Commanders
NFL Week 6 Quick Picks Recap
This recap offers a fast, easy way to see every NFL Week 7 prediction and projected score.
| Date | Matchup | Time (ET) | Predicted Winner | Predicted Score |
|---|---|---|---|---|
| Thu, Oct 9 | Eagles @ Giants | 8:15 PM | Eagles | 30-17 |
| Sun, Oct 12 | Broncos vs Jets (London) | 9:30 AM | Broncos | 27-17 |
| Sun, Oct 12 | Rams @ Ravens | 1:00 PM | Rams | 31-20 |
| Sun, Oct 12 | Cowboys @ Panthers | 1:00 PM | Cowboys | 28-20 |
| Sun, Oct 12 | Cardinals @ Colts | 1:00 PM | Colts | 28-17 |
| Sun, Oct 12 | Seahawks @ Jaguars | 1:00 PM | Seahawks | 24-23 |
| Sun, Oct 12 | Chargers @ Dolphins | 1:00 PM | Chargers | 27-24 |
| Sun, Oct 12 | Browns @ Steelers | 1:00 PM | Steelers | 24-14 |
| Sun, Oct 12 | Patriots @ Saints | 1:00 PM | Patriots | 24-20 |
| Sun, Oct 12 | Titans @ Raiders | 4:05 PM | Raiders | 23-21 |
| Sun, Oct 12 | 49ers @ Buccaneers | 4:25 PM | Buccaneers | 30-27 |
| Sun, Oct 12 | Bengals @ Packers | 4:25 PM | Packers | 31-13 |
| Sun, Oct 12 | Lions @ Chiefs | 8:20 PM | Lions | 34-24 |
| Mon, Oct 13 | Bills @ Falcons | 7:00 PM | Bills | 35-24 |
| Mon, Oct 13 | Bears @ Commanders | 8:15 PM | Commanders | 31-30 |
NFL Week 6 Storylines to Watch
- Detroit’s test of legitimacy: A road win in Kansas City would confirm the Lions as true NFC contenders.
- Mayfield vs McCaffrey showdown: Tampa Bay’s defensive line meets San Francisco’s elite ground game.
- Jalen Hurts’ response: Philadelphia looks to erase last week’s late-game collapse.
- Rookie quarterbacks rising: Drake Maye and Caleb Williams keep shaping the future of their franchises.
- London spotlight: Denver and the Jets continue the NFL’s international push before the Germany series begins.
Explore our NFL Week 6 TV Schedule for every broadcast and streaming option. Grab your Printable NFL Week 6 Pick’em Sheet 2025 to record predictions, write results, and track every game of the week with friends.
