Week 2 of the 2025 NFL season brings the Carolina Panthers to State Farm Stadium to face the Arizona Cardinals. Kickoff is set for Sunday, September 14 at 4:05 PM ET.
Arizona opened the season with a win over the Saints and wants to keep momentum at home. Carolina dropped its first game and needs a stronger showing from quarterback Bryce Young.
This matchup gives the Panthers a chance to bounce back and gives the Cardinals a chance to stay unbeaten.

Where to Watch Panthers vs Cardinals Game Today
CBS will broadcast the game live at 4:05 PM ET. You can stream the CBS feed on Paramount+ if you are in market. NFL+ provides mobile streaming for subscribers.
NFL Sunday Ticket on YouTube and YouTube TV carries the game out of market. Fans who want a trial can also watch on Fubo, which offers a free trial. Check local listings for the CBS channel number in your area.
Panthers vs Cardinals Live Score & Final Results
Our live scoreboard will update in real time once the game begins. After the final whistle you will find the complete score, quarter by quarter results and top player stats.
Panthers vs Cardinals Game Key Statistics
This section will refresh automatically with live data. It will show total yards, passing yards, rushing yards, first downs, turnovers and penalties.
These numbers will reveal whether the Panthers offense can improve after a rough Week 1 and if the Cardinals defense can maintain its strong start.
Panthers vs Cardinals 2025 Preview & Predictions
Sportsbooks list the Cardinals as about 6.5 point favorites with the total points line near 44.5.
Carolina faces injury questions. Left tackle Ikem Ekwonu is working back from an appendectomy and wide receiver Hunter Renfrow has a rib injury. Both are game time decisions. Bryce Young threw two interceptions in Week 1 and will need a clean game to challenge Arizona.
Arizona quarterback Kyler Murray threw two touchdowns in the win over the Saints. Tight end Tip Reiman has a foot injury and linebacker Cody Simon is out with a concussion. The Cardinals running game and balanced offense will look to test a Panthers defense that allowed big rushing yards last week.
Prediction: Cardinals 27 Panthers 17
Arizona has the advantage at home and enough weapons on offense to control the game. Carolina can compete but the Cardinals depth and quarterback play should lead to a second straight win.