Week 2 of the 2025 NFL season brings the San Francisco 49ers to the Caesars Superdome to face the New Orleans Saints. Kickoff is set for Sunday, September 14 at 1:00 PM ET.
Both teams enter this game after uneven starts. The 49ers are adjusting to injuries on offense while the Saints look for their first win with a young quarterback.
The Superdome crowd will give the Saints a loud home field but the 49ers running game will test their defense.
Where to Watch 49ers vs Saints Game Today
FOX will broadcast the game live at 1:00 PM ET. Fans can stream the FOX feed through the Fox Sports app or watch on FOX One, which offers a 7-day free trial.
NFL+ streams the game on mobile devices for subscribers. Check your local listings for the FOX channel number in your area.
49ers vs Saints Live Score & Final Results
Our live scoreboard will update automatically once the game begins. After the final whistle you will find the complete score, quarter by quarter results and top player stats in real time.
49ers vs Saints Game Key Statistics
This section will refresh with live data from our site’s API. It will track total yards, passing yards, rushing yards, first downs, turnovers and penalties.
These numbers will show whether the 49ers ground game can control the pace and if the Saints defense can create pressure on the backup quarterback.
49ers vs Saints 2025 Preview & Predictions
San Francisco comes in as a slight favorite. Sportsbooks list the 49ers at about 3 point favorites with the total points line near 40.5.
Quarterback Brock Purdy is out with a toe injury. Tight end George Kittle is also sidelined. The 49ers will rely on Christian McCaffrey and a strong offensive line if Trent Williams is ready.
New Orleans starts rookie quarterback Spencer Rattler, who is still searching for his first win. The Saints offensive line faces its own issues with Trevor Penning out and Taliese Fuaga questionable. The defense must slow McCaffrey and keep the score within reach.
Prediction: 49ers 23 Saints 17
The 49ers have a deeper roster and a proven running attack. The Saints will battle at home but San Francisco’s defense and ground game should decide the outcome.
