Week 2 of the 2025 NFL season brings the Denver Broncos to Lucas Oil Stadium to face the Indianapolis Colts. Kickoff is set for Sunday, September 14 at 4:05 PM ET.
Both teams opened the season with wins. Denver showed a strong defense in its first game. Indianapolis surprised many with a balanced attack led by Daniel Jones.
This matchup will help set the early tone in the AFC playoff race.

Where to Watch Broncos vs Colts Game Today
CBS will broadcast the game live at 4:05 PM ET. Fans can stream the CBS feed on Paramount+ if they are in market. NFL+ provides mobile streaming for subscribers.
NFL Sunday Ticket on YouTube and YouTube TV carries the game out of market. Fubo also offers a free trial for viewers who want to stream the game. Check your local listings for the CBS channel number.
Broncos vs Colts Live Score & Final Results
Our live scoreboard will update in real time once the game begins. After the final whistle you will find the full score, quarter by quarter results and top player stats.
Also Check: NFL Scores Today 2025
Broncos vs Colts Game Key Statistics
This section will refresh automatically with live data. It will show total yards, passing yards, rushing yards, first downs, turnovers and penalties.
These numbers will reveal whether the Broncos defense can slow the Colts passing game and if Indianapolis can contain the Denver running attack.
Broncos vs Colts 2025 Preview & Predictions
The Broncos enter the game as slight favorites. Sportsbooks list Denver at 1.5 to 2.5 point favorites with the total points line near 43.5.
Indianapolis will be without cornerbacks Charvarius Ward and Jaylon Jones which leaves the secondary thin. Daniel Jones must stay efficient and avoid turnovers to keep the Colts in the game.
Denver will look for rookie quarterback Bo Nix to manage the offense while the defense applies pressure. Tight end Evan Engram has a calf issue and linebacker Dre Greenlaw missed practice but both are expected to be evaluated before kickoff.
Prediction: Broncos 24 Colts 20
Denver’s defense and balanced offense should be enough to secure a close win on the road. Indianapolis can keep it tight but injuries in the secondary give the Broncos an advantage late.