NFL Week 4 Picks 2026: Game-by-Game Predictions & Winners

NFL Week 4 picks 2026 cover all 16 games, from Steelers at Browns on Thursday night to Falcons at Saints on Monday. Every game gets a straight up winner, the injury news that matters and a short reason why.

Week 4 is the last full slate before byes begin, and it opens Sunday with a 9:30 a.m. ET kickoff in London. Backup quarterbacks are again the story. Tampa Bay turns to an undrafted rookie, Chicago turns to Tyson Bagent, Washington starts Marcus Mariota again with Jayden Daniels ruled out, and the Giants play on without Jaxson Dart.

Five teams are still unbeaten in the NFL standings: the Chiefs, Bills, 49ers, Vikings and Raiders. Injury news is current through the final Friday, October 2 injury reports.

We went 10 and 6 in Week 3, and Week 4 opened with a win as the Browns beat the Steelers on Thursday night. Our season record is 31 and 18. For every kickoff and channel, see the NFL Week 4 schedule 2026. These are fan predictions for entertainment only.

Thursday Night Football Result

Pittsburgh Steelers at Cleveland Browns, 8:15 p.m. ET on Prime Video

Both teams came in at 2 and 1. In Week 3, Pittsburgh finally found its offense in a 30 to 27 win over Cincinnati. Jaylen Warren ran for 127 yards at 7.5 a carry, Aaron Rodgers hit two deep touchdown passes and the defense forced a Joe Burrow fumble in the final minute. On Thursday, Warren added 93 yards on 17 carries.

Cleveland won it 27 to 24 when Andre Szmyt hit a 56 yard field goal with 10 seconds left. Deshaun Watson completed 24 of 33 passes for 268 yards, a touchdown and two interceptions, and led a fourth quarter comeback for the third straight week. Rodgers threw for 299 yards and three touchdowns but was picked off twice and sacked five times. The Browns are 3 and 1 and alone in first place in the AFC North, and the Steelers fall to 2 and 2.

Pick: Browns

✅ Final: Browns 27, Steelers 24. Week 4 record: 1 and 0.

Sunday, October 4: London Game Pick (9:30 a.m. ET)

Indianapolis Colts at Washington Commanders, 9:30 a.m. ET on NFL Network, Tottenham Hotspur Stadium, London

Washington is the designated home team. Marcus Mariota threw three touchdowns in a 33 to 31 upset of Seattle, and linebacker Kain Medrano won it with a pick six. Jayden Daniels (dislocated left elbow) practiced in London but has been ruled out, so Mariota starts again. Terry McLaurin (hamstring) is questionable, and guard Sam Cosmi and running back Rachaad White are out. Linebacker Leo Chenal had neck surgery.

Indianapolis beat Houston 19 to 17 on a 53 yard Spencer Shrader field goal with under 20 seconds left. Shrader is 8 for 8 on field goals, but Daniel Jones turned the ball over three times, Alec Pierce is on injured reserve and Keenan Allen has been ruled out. Washington forced three takeaways last week and has the steadier quarterback play right now.

Pick: Commanders

Sunday, October 4: Early Game Picks (1:00 p.m. ET)

Tennessee Titans at Baltimore Ravens (CBS)

Baltimore beat Dallas 34 to 31 in Rio de Janeiro, with Lamar Jackson’s 27 yard throw to Zay Flowers setting up the winning score. Pass rusher Trey Hendrickson (finger) and centers Jovaughn Gwyn (ankle) and Ethan Pocic (knee) are out, and rookie receiver Ja’Kobi Lane is on injured reserve with a fractured wrist.

Tennessee is 0 and 3 after Cam Ward threw an interception from the 7 yard line in the final 30 seconds of a 12 to 7 loss to the Giants. Tony Pollard was cleared to play, while Tyjae Spears (ankle) is questionable. This is the easiest call on the board.

Pick: Ravens

New England Patriots at Buffalo Bills (CBS)

Buffalo is 3 and 0 after a 24 to 16 win over the Chargers, even with five giveaways. James Cook ran for 154 yards, and Josh Allen made the plays when it mattered.

New England lost 35 to 6 in Jacksonville. Drake Maye threw two interceptions, one from the 2 yard line, and lost a fumble, and Mike Vrabel called his concern level very high. Cornerback Christian Gonzalez and defensive tackle Christian Barmore (both shoulder) are out, and A.J. Brown (high ankle sprain) cannot return before Week 6. Orchard Park is a hard place to fix all of that.

Pick: Bills

New York Jets at Chicago Bears (FOX)

Case Keenum, 38 and on his eighth team, threw two touchdowns in a 27 to 7 win over Philadelphia, and the defense forced three turnovers. Caleb Williams (Grade 2 hamstring) is out again, and NFL Network reports Tyson Bagent will start after taking most of the first team reps this week, with Keenum as the backup. Either way, the Bears showed they can win without Williams.

The Jets came back from two touchdowns down in Detroit before losing 31 to 24. Geno Smith threw for 321 yards and three scores. Breece Hall (quad), tight end Mason Taylor (thumb) and receiver Adonai Mitchell (finger) are out, and Omar Cooper is on injured reserve.

Pick: Bears

Jacksonville Jaguars at Cincinnati Bengals (CBS)

Jacksonville is 2 and 1 and rolled New England 35 to 6. Travis Hunter picked off his first career pass and the defense forced three turnovers.

Cincinnati is also 2 and 1 but let Pittsburgh score 30, and Joe Burrow fumbled away the chance to win in the final minute. Safety Kyle Dugger (quad) is out and Andrei Iosivas is on injured reserve. The Jaguars are playing the better all around football, so we take them on the road.

Pick: Jaguars

Dallas Cowboys at Houston Texans (FOX)

Dallas is 1 and 2 after losing 34 to 31 to Baltimore in Rio. The Cowboys drove to the Ravens’ 2 yard line in the final seconds and did not score. Dak Prescott and the offense are moving the ball, and that travels, even with DeMarvion Overshown and Cobie Durant (both hamstring) out again.

Houston is 0 and 3 and scored 17 points in a loss to the Colts. Nico Collins (hamstring) missed two games but was a full participant Friday and carries no injury designation, so he returns. Tank Dell is on injured reserve and Jayden Higgins tore his ACL. The Texans cannot run the ball or sustain drives right now.

Pick: Cowboys

Arizona Cardinals at New York Giants (CBS)

The Giants are 2 and 1 after a 12 to 7 win in heavy rain, with Dominic Zvada kicking four field goals. But they lost pass rusher Brian Burns to a torn ACL, Jaxson Dart is out for the regular season and the team traded for J.J. McCarthy this week. Jameis Winston started in Week 3. Arizona will be without safety Dadrion Taylor-Demerson (back).

Arizona is 1 and 2 but scored 30 points in San Francisco and kept fighting until the end of a 36 to 30 loss. With the Giants losing their best pass rusher and still sorting out quarterback, this is our upset.

Pick: Cardinals

Los Angeles Rams at Philadelphia Eagles (FOX)

Philadelphia was beaten 27 to 7 in Chicago. Jalen Hurts threw an interception in the end zone and the defense allowed 375 yards. The injury list is long: Dallas Goedert (knee), DeVonta Smith (hamstring), Marquise Brown (ankle) and linebacker Zack Baun (concussion) are all out, and Eli Stowers is on injured reserve.

The Rams led Denver 16 to 0 at halftime, gained 482 yards and still lost 30 to 26. Puka Nacua (groin) practiced fully and has no injury designation, so he is back, while tight end Terrance Ferguson (ankle) is out and Myles Garrett is on injured reserve. Nacua’s return makes this closer, but the Eagles at home after a bad loss is still the call.

Pick: Eagles

Green Bay Packers at Tampa Bay Buccaneers (FOX)

Baker Mayfield dislocated his right thumb and will miss at least three weeks. Undrafted rookie Jalon Daniels from Kansas makes his first start. It is the first time in four years Tampa Bay starts someone other than Mayfield. The Bucs are 0 and 3, Minnesota sacked Mayfield six times, Jalen McMillan is on injured reserve and pass rusher Rueben Bain Jr. and cornerback Benjamin Morrison are out.

Green Bay is 1 and 2 after a 35 to 14 loss to Atlanta that Matt LaFleur called a humbling night. Josh Jacobs remains on the commissioner exempt list, and Jayden Reed went on injured reserve on September 30 with a season ending neck injury. The Packers have problems, but a rookie quarterback on his first start is a bigger one.

Pick: Packers

Sunday, October 4: Late Game Picks (4:05 and 4:25 p.m. ET)

Miami Dolphins at Minnesota Vikings, 4:05 p.m. ET (FOX)

Minnesota is 3 and 0. The defense sacked Baker Mayfield six times in a 23 to 16 win, with Kyle Van Noy getting three, and a punt return touchdown decided it. Justin Jefferson (ankle sprain) has been ruled out, and tight end Josh Oliver tore his biceps.

Miami is 0 and 3 and lost De’Von Achane to a torn ACL for the season. Jaylen Wright practiced fully and has no designation, but the run game is thin. The Dolphins move the ball between the 20s but cannot finish drives. Even without Jefferson, the Vikings defense is the best unit in this game.

Pick: Vikings

Kansas City Chiefs at Las Vegas Raiders, 4:25 p.m. ET (CBS)

Two unbeaten teams. Patrick Mahomes completed 20 of 24 passes in a 24 to 10 win over Miami, and Kenneth Walker III has given the Chiefs a steady run game.

Las Vegas is 3 and 0 after a 35 to 27 win in New Orleans. Brock Bowers caught 10 passes for 116 yards and a touchdown, and Kirk Cousins is playing well. Receiver Jack Bech broke his forearm and center Jackson Powers-Johnson (groin) is out. The Raiders are for real, but Mahomes has been sharp and the Chiefs have more ways to win a close one.

Pick: Chiefs

Los Angeles Chargers at Seattle Seahawks, 4:25 p.m. ET (CBS)

Seattle lost 33 to 31 in Washington as Sam Darnold threw two interceptions, one returned for a touchdown. Safety Julian Love (calf) practiced fully and has no designation. Even so, the Seahawks are 2 and 1 and very tough at home.

The Chargers are 0 and 3. They forced three turnovers in the first half in Buffalo and then fell apart after halftime. David Njoku is on injured reserve, Charlie Kolar (forearm) is out and Justin Herbert has struggled with accuracy.

Pick: Seahawks

Denver Broncos at San Francisco 49ers, 4:25 p.m. ET (CBS)

San Francisco is 3 and 0 and ranked first in the NFL.com Week 4 power rankings. Kyle Shanahan called an 82 yard hook and ladder touchdown on third and 12 in a 36 to 30 win over Arizona. Nick Bosa (knee, calf) has been ruled out and Mike Evans (ribs) is questionable. Ricky Pearsall is out for the season and Demarcus Robinson has a high ankle sprain.

Denver came back from 16 to 0 down to beat the Rams 30 to 26, with Talanoa Hufanga returning an interception for a touchdown and sealing it with another. Rookie Jonah Coleman is on injured reserve. The Broncos defense is good enough to keep this close, but the 49ers offense is playing at another level.

Pick: 49ers

Sunday Night Football Pick

Detroit Lions at Carolina Panthers, 8:20 p.m. ET on NBC and Peacock

Jahmyr Gibbs had 164 yards and three touchdowns in a 31 to 24 win over the Jets. Jared Goff has 802 passing yards, eight touchdowns and no interceptions through three games, and Amon-Ra St. Brown has five touchdown catches. Detroit is missing safety Kerby Joseph and cornerback Avonte Maddox.

Carolina is 1 and 2 after losing 21 to 18 in Cleveland. Jaycee Horn (quad) and Mike Jackson (groin) are on injured reserve, Jalen Coker (quad) is questionable and Xavier Legette (knee) is out. Goff against a banged up secondary is the edge.

Pick: Lions

Monday Night Football Pick

Atlanta Falcons at New Orleans Saints, 8:15 p.m. ET on ESPN

Atlanta has had 11 days to prepare since routing Green Bay 35 to 14 on Thursday night, with Michael Penix Jr. and Bijan Robinson leading the way. Both teams are 1 and 2.

Tyler Shough threw a career high four touchdown passes against Las Vegas, but he also had four turnovers in the fourth quarter of a 35 to 27 loss. Travis Etienne Jr. (hamstring) and receiver Jordyn Tyson are on injured reserve, and linebacker Kaden Elliss and defensive ends Carl Granderson and Anfernee Jennings are out. Atlanta has no one ruled out, with Divine Deablo and Samson Ebukam questionable. The Falcons have the better run game and the extra rest.

Pick: Falcons

NFL Week 4 Picks 2026: Quick Recap Table

Date	Matchup	Time (ET)	TV	Pick
Thu, Oct 1	Steelers at Browns	8:15 PM	Prime Video	Browns ✅ (CLE 27, PIT 24)
Sun, Oct 4	Colts at Commanders (London)	9:30 AM	NFL Network	Commanders
Sun, Oct 4	Titans at Ravens	1:00 PM	CBS	Ravens
Sun, Oct 4	Patriots at Bills	1:00 PM	CBS	Bills
Sun, Oct 4	Jets at Bears	1:00 PM	FOX	Bears
Sun, Oct 4	Jaguars at Bengals	1:00 PM	CBS	Jaguars
Sun, Oct 4	Cowboys at Texans	1:00 PM	FOX	Cowboys
Sun, Oct 4	Cardinals at Giants	1:00 PM	CBS	Cardinals
Sun, Oct 4	Rams at Eagles	1:00 PM	FOX	Eagles
Sun, Oct 4	Packers at Buccaneers	1:00 PM	FOX	Packers
Sun, Oct 4	Dolphins at Vikings	4:05 PM	FOX	Vikings
Sun, Oct 4	Chiefs at Raiders	4:25 PM	CBS	Chiefs
Sun, Oct 4	Chargers at Seahawks	4:25 PM	CBS	Seahawks
Sun, Oct 4	Broncos at 49ers	4:25 PM	CBS	49ers
Sun, Oct 4	Lions at Panthers (SNF)	8:20 PM	NBC	Lions
Mon, Oct 5	Falcons at Saints (MNF)	8:15 PM	ESPN	Falcons

Home teams: 9. Road teams: 7. Upset: Cardinals over Giants. Closest calls: Jaguars at Bengals, Rams at Eagles and Chiefs at Raiders. Week 4 record so far: 1 and 0. Season record: 31 and 18.

Running a pool? Print the free NFL Week 4 pick’em sheet. Week 4 is the last week with no byes, so all 32 teams play. Check NFL bye weeks before Week 5.

How Our Week 3 Picks Did

We went 10 and 6 in Week 3. Correct: Bills, Browns, Lions, Colts, Jaguars, Chiefs, 49ers, Vikings, Ravens and Broncos. Wrong: Packers, Titans, Bengals, Seahawks, Saints and Eagles. The Broncos call on Sunday night came through after a 16 point comeback, while the Titans and Saints upset picks both missed. Our record is 12 and 4 in Week 1, 8 and 8 in Week 2 and 10 and 6 in Week 3.

Week 4 Final Injury Report: Statuses That Shape the Picks

• Quarterbacks: Baker Mayfield (TB, dislocated thumb) out, rookie Jalon Daniels starts. Caleb Williams (CHI, hamstring) out, Tyson Bagent expected to start. Jayden Daniels (WAS, elbow) out, Marcus Mariota starts. Jaxson Dart (NYG) out for the regular season, Jameis Winston started Week 3.
• Out for the season: De’Von Achane (MIA, ACL), Brian Burns (NYG, ACL), Jayden Higgins (HOU, ACL), Ricky Pearsall (SF), Leo Chenal (WAS, neck surgery), Josh Oliver (MIN, biceps), Jayden Reed (GB, neck).
• Ruled out for Week 4: Justin Jefferson (MIN), Nick Bosa (SF), DeVonta Smith, Zack Baun, Marquise Brown and Dallas Goedert (PHI), Trey Hendrickson (BAL), Breece Hall (NYJ), Keenan Allen (IND), Christian Gonzalez (NE), Kyle Dugger (CIN), Jackson Powers-Johnson (LV).
• On injured reserve: Jaycee Horn (CAR), Travis Etienne Jr. (NO), Jordyn Tyson (NO), Tank Dell (HOU), Alec Pierce (IND), David Njoku (LAC), Myles Garrett (LAR), Jalen McMillan (TB), Ja’Kobi Lane (BAL), Andrei Iosivas (CIN), Jonah Coleman (DEN). A.J. Brown (NE) is not eligible until Week 6.
• Questionable: Terry McLaurin (WAS, hamstring), Mike Evans (SF, ribs), Jalen Coker (CAR, quad), Tyjae Spears (TEN, ankle), Divine Deablo and Samson Ebukam (ATL, hamstring).
• Cleared to play: Puka Nacua (LAR), Nico Collins (HOU), Tony Pollard (TEN), Jaylen Wright (MIA), Julian Love (SEA).
• Not playing: Josh Jacobs (GB) remains on the commissioner exempt list.

These are the final game statuses from Friday, October 2. Teams can still make roster moves before kickoff, so check inactives 90 minutes before each game.

FAQs About NFL Week 4 Picks 2026

NFL Week 4 picks 2026 come down to backup quarterbacks and a few big unbeaten matchups. The Ravens, Bills and 49ers are our strongest calls, Cardinals over Giants is the upset, and Chiefs at Raiders is the game of the week. The Browns pick is already in, and the final reports settled the big questions: Nacua and Collins play, while Jefferson, Bosa and Jayden Daniels sit.